Typical domestic exposures are of approximately 100 Bq/m³ indoors. Depending on how houses are built and ventilated, radon may accumulate in basements and dwellings. Radon concentrations in the same location may differ by a factor of two over a period of 1 hour. Also, the concentration in one room of a building may be significantly different than the concentration in an adjoining room.

The distribution of radon concentrations tends to be asymmetrical around the average, the larger concentrations have a disproportionately greater weight. Indoor radon concentration is usually assumed to follow a lognormal distribution on a given territory.Thus, the geometric mean is generally used for estimating the "average" radon concentration in an area. The mean concentration ranges from less than 10 Bq/m³ to over 100 Bq/m³ in some European countries. Typical geometric standard deviations found in studies range between 2 and 3, meaning (given the 68-95-99.7 rule) that the radon concentration is expected to be more than a hundred times the mean concentration for 2 to 3% of the cases.

The highest average radon concentrations in the United States are found in Iowa and in the Appalachian Mountain areas in southeastern Pennsylvania.Some of the highest readings ever have been recorded in the Irish town of Mallow, County Cork, prompting local fears regarding lung cancer. Iowa has the highest average radon concentrations in the United States due to significant glaciation that ground the granitic rocks from the Canadian Shield and deposited it as soils making up the rich Iowa farmland. Many cities within the state, such as Iowa City, have passed requirements for radon-resistant construction in new homes. In a few locations, uranium tailings have been used for landfills and were subsequently built on, resulting in possible increased exposure to radon.

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